Laufende Studien

ADAPT late
adjuvant
HR+/HER2- Mammakarzinom
Phase III

Eine randomisierte, offene, adjuvante, an dynamischen Markern adjustierte, personalisierte Therapiestudie der Phase-III zum Vergleich der Therapie von Abemaciclib plus endokriner Standardtherapie gegenüber alleiniger adjuvanter endokriner Standardtherapie bei Hormonrezeptor-positivem, HER2-Rezeptor negativem Brustkrebs im Frühstadium mit klinisch oder genomisch hohem Risiko für ein Spätrezidiv.

GeparPiPPa
neoadjuvant
HER2+/HR+/PIK3CA mutiertes Mammakarzinom
Phase II

A randomized, open-label, phase II trial comparing neoadjuvant endocrine therapy in combination with trastuzumab, pertuzumab +/- the PI3K inhibitor inavolisib in patients with HER2-positive, HR-positive, PIK3CA mutant early breast cancer

CO44194
palliativ
triple negatives Mammakarzinom
Phase II

A Study of Tobemstomig + Nab-Paclitaxel Compared With Pembrolizumab + Nab-Paclitaxel in Participants With Previously Untreated, PD-L1-Positive, Locally-Advanced Unresectable or Metastatic Triple-Negative Breast Cancer

TROPION-Breast02
palliativ
triple negatives Mammakarzinom
Phase III

A Study of Dato-DXd Versus Investigator's Choice Chemotherapy in Patients With Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer, Who Are Not Candidates for PD-1/PD-L1 Inhibitor Therapy (TROPION-Breast02)

SERENA-6
palliativ
HR+/HER2- Mammakarzinom
Phase III

A Phase III, Double-blind, Randomised Study to Assess Switching to AZD9833 (a Next Generation, Oral SERD) + CDK4/6 Inhibitor (Palbociclib or Abemaciclib) vs Continuing Aromatase Inhibitor (Letrozole or Anastrozole)+ CDK4/6 Inhibitor in HR+/HER2-MBC Patients With Detectable ESR1Mutation Without Disease Progression During 1L Treatment With Aromatase Inhibitor+ CDK4/6 Inhibitor- A ctDNA Guided Early Switch Study

IMMU-132-06/TROPHY-U-01
palliativ
Urothelkarzinom
Phase II

A Phase II Open-Label Study of Sacituzumab Govitecan in Unresectable Locally Advanced/Metastatic Urothelial Cancer

DREAMM-9 (209664)
nicht-transplantables
Multiples Myelom
Phase I

Randomisierte Phase-I-Studie zur Auswertung von Dosis und Verabreichungsschema zur Untersuchung der Sicherheit, Pharmakokinetik, Pharmakodynamik und klinischen Aktivität von Belantamab-Mafodotin in Kombination mit einer Standardtherapie bei Patienten mit neu diagnostiziertem Multiplen Myelom.

CLL 16
first line CLL, Hochrisiko
Phase III

A Prospective, Open-label, Multicentre, Randomized, Phase-3-trial of Acalabrutinib, Obinutuzumab and Venetoclax (GAVE) Compared to Obinutuzumab and Venetoclax (GVE) in Previously Untreated Patients With High Risk (17P-deletion, TP53-mutation or Complex Karyotype) Chronic Lymphatic Leukemia (CLL)

NHL 3-2004
Primärtherapie Haarzell-Leukämie
Therapieoptimierungsstudie

Therapy Optimisation for the Treatment of Hairy Cell Leukemia

ELEMENT-MDS
Myelodysplastisches Syndrom
Neu diagnostiziert, ESA naiv
Phase III

A Phase 3, Open-label, Randomized Study to Compare the Efficacy and Safety of Luspatercept (ACE-536) vs Epoetin Alfa for the Treatment of Anemia Due to Revised International Prognostic Scoring System (IPSS-R) Very Low, Low, or Intermediate Risk Myelodysplastic Syndrome (MDS) in Erythropoietin-stimulating Agent (ESA)-naive Participants who are Non-Transfusion Dependent (NTD)