Laufende Studien

CAMBRIA-2
adjuvant
HR+/HER2- Mammakarzinom
Phase III

A Phase III, Open-Label, Randomised Study to Assess the Efficacy and Safety of Camizestrant (AZD9833, a Next Generation, Oral Selective Estrogen Receptor Degrader) Versus Standard Endocrine Therapy (Aromatase Inhibitor or Tamoxifen) as Adjuvant Treatment for Patients with ER+/HER2- Early Breast Cancer and an Intermediate-High or High Risk of Recurrence Who Have Completed Definitive Locoregional Treatment and Have No Evidence of Disease.

ADAPT late
adjuvant
HR+/HER2- Mammakarzinom
Phase III

Eine randomisierte, offene, adjuvante, an dynamischen Markern adjustierte, personalisierte Therapiestudie der Phase-III zum Vergleich der Therapie von Abemaciclib plus endokriner Standardtherapie gegenüber alleiniger adjuvanter endokriner Standardtherapie bei Hormonrezeptor-positivem, HER2-Rezeptor negativem Brustkrebs im Frühstadium mit klinisch oder genomisch hohem Risiko für ein Spätrezidiv.

GeparPiPPa
neoadjuvant
HER2+/HR+/PIK3CA mutiertes Mammakarzinom
Phase II

A randomized, open-label, phase II trial comparing neoadjuvant endocrine therapy in combination with trastuzumab, pertuzumab +/- the PI3K inhibitor inavolisib in patients with HER2-positive, HR-positive, PIK3CA mutant early breast cancer

eVOLVE-Lung02
metastasiertes NSCLC
PD-L1 Status <50%
1^st line Therapie
Phase III

A Phase III, Two-Arm, Parallel, Randomized, Multi-Center, Open-Label, Global Study to Determine the Efficacy of Volrustomig (MEDI5752) Plus Chemotherapy Versus Pembrolizumab Plus Chemotherapy for First-Line Treatment of Patients with Metastatic Non-Small Cell Lung Cancer (mNSCLC) (eVOLVE-Lung02)

IMMU-132-06/TROPHY-U-01
palliativ
Urothelkarzinom
Phase II

A Phase II Open-Label Study of Sacituzumab Govitecan in Unresectable Locally Advanced/Metastatic Urothelial Cancer

BELLWAVE-011
CLL/SLL
1^st line Therapie
Phase III

A Phase 3, Randomized Study to Compare Nemtabrutinib Versus Comparator (Investigator’s Choice of Ibrutinib or Acalabrutinib) in Participants With Untreated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

CLL 16
Hochrisiko CLL
1^st line Therapie
Phase III

A Prospective, Open-label, Multicentre, Randomized, Phase-3-trial of Acalabrutinib, Obinutuzumab and Venetoclax (GAVE) Compared to Obinutuzumab and Venetoclax (GVE) in Previously Untreated Patients With High Risk (17P-deletion, TP53-mutation or Complex Karyotype) Chronic Lymphatic Leukemia (CLL)

NHL 3-2004
Primärtherapie Haarzell-Leukämie
Therapieoptimierungsstudie

Therapy Optimisation for the Treatment of Hairy Cell Leukemia

ELEMENT-MDS
Myelodysplastisches Syndrom
Neu diagnostiziert, ESA naiv
Phase III

A Phase 3, Open-label, Randomized Study to Compare the Efficacy and Safety of Luspatercept (ACE-536) vs Epoetin Alfa for the Treatment of Anemia Due to Revised International Prognostic Scoring System (IPSS-R) Very Low, Low, or Intermediate Risk Myelodysplastic Syndrome (MDS) in Erythropoietin-stimulating Agent (ESA)-naive Participants who are Non-Transfusion Dependent (NTD)

Deutschsprachige Informationen für Patienten und Angehörige finden Sie hier 

GOLSEEK-1
Hochrisiko DLBCL
1^st line Therapie
Phase III

A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study Comparing the Efficacy and Safety of Golcadomide Plus R-CHOP Chemotherapy vs Placebo Plus R-CHOP Chemotherapy in Participants with Previously Untreated High-risk Large B-cell Lymphoma

SYBIL
palliativ
Solide Tumoren
Beobachtungs-/Diagnostikstudie

SIBYL: obServation of therapy response with lIquid BiopsY evaLuation